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MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E-2-mediated M2 generation
(Public Library Science, 2015-02-23)
Macrophages dictate both initiation and resolution of inflammation. During acute inflammation classically activated macrophages (M1) predominate, and during the resolution phase alternative macrophages (M2) are dominant. ...
Junin virus triggers macrophage activation and modulates polarization according to viral strain pathogenicity
(Frontiers Media S.A., 2019-10)
The New World arenavirus Junin (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF). Previous studies of human macrophage infection by the Old-World arenaviruses Mopeia and Lassa showed that while the ...
Tissue repairing macrophage phenotype is induced by direct interaction with platelets
(2016)
INTRODUCTION: Tissue repair process requires of specialized cells as macrophages.
These cells must be stimulated properly to induce tissue repairing macrophage to finally
heal tissue. Platelets contain many factors that ...
M1 macrophage polarization prevails in EBV infected children in an immuneregulatory environment
(American Society for Microbiology, 2021-10-29)
Macrophages can be polarized toward a proinflammatory phenotype (M1) (CD68+) or to an anti-inflammatory one (M2) (CD163+). Polarization can be triggered by cytokines such as IFN-γ for M1, or IL-10 and TGF-β, for M2. In the ...